California’s Office of Environmental Health Hazard Assessment (OEHHA) announced it intends to list six nitrobenzene chemical candidates and other industrial chemicals as carcinogens under Proposition 65.
The nitrobenzene compounds included in the proposed listing include:
OEHHA intends to list the chemical candidates named above by the Labor Code’ listing mechanism to add the proposed chemicals to the Proposition 65 List of Carcinogens.
The proposed listings were based on determinations made by the International Agency for Research on Cancer (IARC) that the substances are possibly carcinogenic to humans (Group 2B), based on sufficient evidence of carcinogenicity in animals.
When finalized, businesses will be required to provide Prop 65 warnings where there are exposures to these chemicals above ‘Safe Harbor’ thresholds if and when they are established by the agency.
- 2-Amino-4-chlorophenol is a light brown colored crystalline solid. that may be toxic by ingestion. It is insoluble in water. It is used as an intermediate to create other chemical compounds.
2-Nitrochlorobenzene is an organic compound with the formula ClC₆H₄NO₂. It is one of three isomeric nitrochlorobenzenes. It is a yellow crystalline solid that is important as a precursor to other compounds due to its two functional groups.
1,2-Dichloro-4-nitrobenzene is an organic compound with the formula 1,2-Cl₂C₆H₃-4-NO₂. This pale yellow solid is related to 1,2-dichlorobenzene by the replacement of one H atom with a nitro functional group. This compound is an intermediate in the synthesis of agrochemicals.
- N, N-dimethylacetamide N, N-dimethylacetamide is a member of the class of acetamides that is acetamide in which the hydrogens attached to the N atom have been replaced by two methyl groups respectively.
- Metabolite observed in cancer metabolism has a role as a human metabolite. It is a member of acetamides and a monocarboxylic acid amide. It derives from an acetamide.
- Para-nitro anisole.
4-nitro anisole CAS# 100-17-4 Chemical Formula C7H7NO3
OEHHA is proposing the listings via the “Labor Code” listing mechanism to make the additions, which are based
The public comment period for the on the proposed listings will be open through August 1, August 12, 2019.
OEHHA notes that this is a “ministerial listing” process, and it cannot consider scientific arguments concerning the weight or quality of evidence considered by IARC. “Comments should be limited to whether IARC has identified the specific chemical or substance as a known or potential human or animal carcinogen,” the agency said in its July 12 regulatory notice.