Cal/EPA’s Developmental and Reproductive Toxicant Identification Committee (Dart-IC) has set priorities for the development of hazard identification materials for five chemicals and substances.
The committee met on Nov. 9 to determine which chemicals and substances should be considered for listing as Proposition 65 reproductive toxicants next. PFOA and PFOS were designated as ‘high’ priorities.
The committee selected the following substances, which are listed from highest to lowest:
Perfluorooctanoic acid (PFOA) – high
Perfluorooctane sulfonate (PFOS) – high.
Pentachlorophenol (PCP) – medium/high;
Tetrachloroethylene (PCE) – medium/high;
Nickel & nickel compounds –medium /low;
The preparation of hazard identification materials can serve as a precursor to a substance being listed on Prop 65 as a reproductive or developmental toxicant.
The committee also considered whether to maintain the listed status of methyl-n-butyl ketone as a reproductive toxicant, following changes to the OSHA regulation on which this had been based.
The committee agreed by a vote of 6-to 2 that the chemical should remain on the Prop 65 list, and voted 6-2 to add the developmental toxicity endpoint to its listing.
The committee also voted unanimously to list 2,5-Hexanedione– a metabolite of methyl-n-butyl ketone – as a reproductive toxicant.
DART-IC asked that the following substances be considered as candidates for listing, at a future meeting:
polybrominated diphenyl ethers (PBDEs);
Two of the chemicals selected by the committee for prioritization are already included on the Proposition 65 list of carcinogens.
Tetrachloroethylene (PCE) and Nickel and nickel compounds are presently listed as carcinogens, and may join a small group of chemicals that cause both cancer and reproductive toxicity. Both chemicals have been listed as carcinogens for many years.
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