California’s Office of Environmental Health Hazard Assessment (OEHHA) has released Hazard Identification Documents for two chemicals that will be considered for delisting at the state’s Carcinogen Identification Committee (CIC) meeting on November 4.
The CIC will consider whether nitrapyrin and diaminotoluene (mixed) should be removed from the Proposition 65 list of carcinogens.
Nitrapyrin (CAS No. 1929-82-4) was listed as a Proposition 65 carcinogen on October 5, 2005, based upon its classification by the US Environmental Protection Agency in a 2000 report as “likely to be carcinogenic in humans.” In 2012, US EPA revised the classification of nitrapyrin to “Suggestive Evidence of Carcinogenic Potential” (US EPA, 2012a).
When a chemical is no longer identified by the authoritative body as causing cancer and no other administrative basis for listing applies, the chemical is referred to the CIC which then determines whether the chemical has been “clearly shown through scientifically valid testing according to generally accepted principles to cause cancer.” If the CIC makes such a determination, the chemical remains on the Proposition 65 list. Otherwise, the chemical is removed from the list.
Diaminotoluene (mixed) was listed as a Proposition 65 carcinogen on January 1, 1990, based upon its classification by the US Environmental Protection Agency (US EPA, 1988) as a Group B2 carcinogen (probable human carcinogen). OEHHA received a petition from Big Lots Stores, Inc. for reconsideration of listing for diaminotoluene (mixed) on October 21, 2014. While the US EPA (1988) basis document indicates that the hazard ranking of diaminotoluene (mixed) “is applicable to all isomers of diaminotoluene”, and that the “evidence on potential carcinogenicity from animal studies is “sufficient”, the US EPA document also indicates that “this evidence is based on the carcinogenic properties of the isomer 2,4-diaminotoluene”. No other information on the mixture or individual isomers is included in the EPA document.
OEHHA is referring diaminotoluene (mixed) to the CIC for a determination as to whether the chemical should remain on the Proposition 65 list.
The CIC will determine whether or not diaminotoluene (mixed) has been “clearly shown through scientifically valid testing according to generally accepted principles to cause cancer” and should remain on the Proposition 65 list. The CIC will also determine whether or not diaminotoluenes as a group, or any of the five individual diaminotoluene isomers not currently listed as causing cancer, should be added to the list.
OEHHA is seeking public comments concerning the potential delistings of whether nitrapyrin and diaminotoluene (mixed) through October 12, 2015.
Comments transmitted by e-mail should be addressed to P65Public.Comments@oehha.ca.gov. Please include “HIM – Nitrapyrin” or “HIM – Diaminotoluenes” in the subject line.
Comments may also be submitted in paper form and mailed, faxed, or delivered to:
Office of Environmental Health Hazard Assessment
P.O. Box 4010, MS-12B
Sacramento, California 95812-4010
Fax: (916) 323-2265
Street Address: 1001 I Street
Sacramento, California 95814
Notice – Availability of Hazard Identification Materials for Nitrapyrin and Diaminotoluenes. “Diaminotoluene (mixed)” and Nitrapyrin are Under Review for Possible Delisting and Meeting of the Carcinogen Identification Committee (CIC) November 4, 2015
Nitrapyrin. A Chemical Listed “As Causing Cancer” by the Authoritative Bodies Mechanism and under Review by the Carcinogen Identification Committee
US EPA 1992 Carcinogenicity Peer Review of Nitrapyrin
US EPA 2000, Nitrapyrin (second Review) – Report of the Cancer Assessment Review Committee
USEPA 2005, NITRAPYRIN: Report of the Cancer Assessment Review Committee
USEPA 2012, Nitrapyrin: Fourth Report of the Cancer Assessment Review Committee
Diaminotoluenes (DATs). “Diaminotoluene (mixed)” Is Listed “As Causing Cancer” by the Authoritative Bodies Mechanism and These Chemicals are under Review by the Carcinogen Identification Committee
IARC Monographs Volume 99 – Occupational Exposures of Hairdressers and Barbers, and Personal Use of Hair Colorants