By Jack Schatz
The Office of Environmental Health Hazard Assessment (OEHHA) today announced it intends to add five new chemicals to the Proposition 65 chemical list via the Labor Code Listing mechanism.
The chemicals include: Estrogen–progestogen (combined) used as menopausal therapy, Etoposide, etoposide in combination with cisplatin and bleomycin, methyl isobutyl ketone, and MOPP (vincristine-prednisone-nitrogen mustard-procarbazine mixture).
OEHHA cites the inclusion of each of the chemicals, except methyl isobutyl ketone in the International Agency on Research for Cancer (IARC’s) published Volume 100A of its series, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans (IARC, 2011a). Each of the chemicals listed in this monograph were classified as (Group 1) carcinogenic to humans.
IARC has concluded that methyl isobutyl ketone is classified in (Group 2B) “possibly carcinogenic to humans”). IARC also concluded that there is “sufficient evidence of carcinogenicity in experimental animals” for it classification.
Estrogen–progestogen (combined) used as menopausal therapy Combined estrogen–progestogen menopausal therapy involves the co-administration of an estrogen and a progestogen to peri- or menopausal
women. The use of estrogens with progestogens has been recommended to prevent the estrogen-associated risk of endometrial cancer. Evidence from the Women’s Health Initiative (WHI) of adverse effects from the use of a continuous combined estrogen–progestogen has affected prescribing. Patterns of exposure are also changing rapidly as the use of hormonal therapy declines, the indications are restricted, and the duration of the therapy is reduced.
Etoposide is a chemotherapy drug that is usually given to treat lung, ovarian and testicular cancer. It is usually administered by intravenous drip or by tablet.
Etoposide in combination with cisplatin and bleomycin
Etoposide in combination with cisplatin and bleomycin is a chemotherapy drug used to treat testicular cancer.
Methyl Isobutyl Ketone
Methyl isobutyl ketone (MIBK) is used as a solvent for gums, resins, paints, varnishes, lacquers, and nitrocellulose.
The largest users of MIBK are companies that add it to protective surface coatings. Other companies add MIBK to adhesives, printing ink, and special lubricating oils. MIBK is also used to make pesticides and to separate and purify several other organic and inorganic chemicals. Drug companies use MIBK to extract and purify antibiotics and other drugs. It is also used in the manufacture of textiles and leather.
MOPP (vincristine-prednisone-nitrogen mustard-procarbazine mixture).
MOPP (vincristine-prednisone-nitrogen mustard-procarbazine mixture) is a treatment for Hodkin’s Lymphoma, primarily used in treating children. Even though radiation therapy is usually the treatment of choice for the adult patients with Hodgkin’s disease, chemotherapy is usually chosen over radiation therapy for the treatment of children, because children with fast growing bones and soft tissues are more sensitive to effects of radiation therapy.